Stephen N. Waggoner

This study identifies HIF-2 as a critical factor for the survival of cytokine-activated human NK cells, showing it is induced by IL-2/IL-15 and not hypoxia, and its inhibition reduces NK cell viability.

This study uses single nucleus RNA sequencing to identify altered angiogenic signaling in JDM muscle, highlighting vascular and IFN pathways.

This study shows that Ddx3x is essential for B-cell development in mice, with loss leading to developmental blocks and defects in immunoglobulin rearrangement.

This study improves NK cell transfer models in mice by showing that CRISPR-generated JAXBoy NK cells persist better than conventional BoyJ cells, and identifies roles for CXCR3 and ASCL2 in splenic NK cell localization during virus infection.

This study identifies LAG3 as a marker of dysfunctional NK cells that are activated but hyporesponsive in various inflammatory conditions.

This study shows that prothrombin prevents fatal T cell-dependent anemia in mice during chronic viral infection by reducing hemolysis, not by affecting T cell function or viral load.

The paper maps promoter interactions in human ILC3s using PCHi-C and links GWAS risk variants to target genes, identifying new autoimmune disease risk genes.

The paper investigates how genetic, inflammatory, and epithelial cell differentiation factors regulate CAPN14 expression in eosinophilic esophagitis.