H. Alex Feldman

Hypoxia-inducible factor 2-alpha promotes fitness of cytokine-activated human natural killer cells

This study identifies HIF-2 as a critical factor for the survival of cytokine-activated human NK cells, showing it is induced by IL-2/IL-15 and not hypoxia, and its inhibition reduces NK cell viability.

Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection

This study improves NK cell transfer models in mice by showing that CRISPR-generated JAXBoy NK cells persist better than conventional BoyJ cells, and identifies roles for CXCR3 and ASCL2 in splenic NK cell localization during virus infection.

Prothrombin prevents fatal T cell-dependent anemia during chronic virus infection of mice

This study shows that prothrombin prevents fatal T cell-dependent anemia in mice during chronic viral infection by reducing hemolysis, not by affecting T cell function or viral load.