ATF4 activates a transcriptional program that chronically suppresses mTOR activity promoting neurodegeneration in Parkinson's disease models
Matthew D. Demmings, Erica A. Kane, Elizabeth C. Tennyson, Kate Hurley, Joy L Zhao, Nichola A. Cruickshanks, Victoria Ciz, Jordan M Krupa, Stephen Pasternak, Sean P. Cregan
This study identifies a mechanism by which chronic ATF4 activation suppresses mTORC1/2 activity, leading to PUMA-mediated neuronal death in Parkinson's disease models.
bioRxiv · Jun 9, 2025 · PreprintNeuroscience