Author

Sean P. Cregan

Western University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Matthew D. DemmingsiD· 2 shared Elizabeth C. Tennyson· 1 shared Erica A. Kane· 1 shared Gillian N. PetroffiD· 1 shared Heather E. Tarnowski-Garner· 1 shared Jordan M KrupaiD· 1 shared Joy L ZhaoiD· 1 shared Kate Hurley· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Matthew D. DemmingsORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 9, 2025

ATF4 activates a transcriptional program that chronically suppresses mTOR activity promoting neurodegeneration in Parkinson's disease models

Matthew D. Demmings, Erica A. Kane, Elizabeth C. Tennyson…·Sean P. Cregan

This study identifies a mechanism by which chronic ATF4 activation suppresses mTORC1/2 activity, leading to PUMA-mediated neuronal death in Parkinson's disease models.

1 citation

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 30, 2019

ATF4 regulates neuronal death in models of Parkinson’s Disease

Matthew D. Demmings, Gillian N. Petroff, Heather E. Tarnowski-Garner, Sean P. Cregan

This study shows ATF4 promotes neuronal death in Parkinson’s Disease models by inducing pro-apoptotic genes and that inhibiting ATF4 protects against neurotoxin-induced cell loss.

3 citations

mousestatistical model

𝕏 PostBluesky