Jordan M Krupa

This study identifies a mechanism by which chronic ATF4 activation suppresses mTORC1/2 activity, leading to PUMA-mediated neuronal death in Parkinson's disease models.

The paper demonstrates that Fe65 links APP to Arf6 and RhoGTPases to regulate macropinocytosis, which is critical for Aβ production in Alzheimer's disease.

This study shows that Arf6 and RhoGTPases Rac1, Cdc42, and RhoA are required for macropinocytosis of Aβ42 oligomers and tau fibrils in neurons, suggesting new targets to prevent their transfer in Alzheimer's disease.

This study shows that lysosomal exocytosis releases amyloid beta from hiPSC-derived neurons, suggesting it as a therapeutic target for Alzheimer's disease.