In-vitro Metabolite Identification for MEDI7219, an Oral GLP-1 Peptide, using LC-MS/MS with CID and EAD Fragmentation
Kate Liu, Yue Huang, Taoqing Wang, Ruipeng Mu, Anton I. Rosenbaum
This study identifies 13 metabolites of the orally-bioavailable GLP-1 peptide MEDI7219 using in vitro pancreatin assays with CID and EAD fragmentation, revealing cleavage sites and enzyme-specific degradation patterns.
Bioanalysis · Jul 3, 2025Peer-reviewedPharmacology & Toxicology