Author

Ruipeng Mu

AstraZeneca (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:non-human primate· 1

Frequent Co-Authors

Anton I. RosenbaumiD· 2 shared B. Timothy HummeriD· 1 shared ChaoYu Jin· 1 shared Joseph S. GrimsbyiD· 1 shared Kate Liu· 1 shared Kristina S. KovacinaiD· 1 shared Meina LiangiD· 1 shared Taoqing Wang· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

Anton I. RosenbaumORCID

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2 papers

Recent·Most cited

In-vitro Metabolite Identification for MEDI7219, an Oral GLP-1 Peptide, using LC-MS/MS with CID and EAD Fragmentation

Kate Liu, Yue Huang, Taoqing Wang, Ruipeng Mu, Anton I. Rosenbaum

This study identifies 13 metabolites of the orally-bioavailable GLP-1 peptide MEDI7219 using in vitro pancreatin assays with CID and EAD fragmentation, revealing cleavage sites and enzyme-specific degradation patterns.

Bioanalysis · Jul 3, 2025Peer-reviewedPharmacology & Toxicology

Inhibition of Endothelial Lipase by MEDI5884 Normalizes Phosphatidylinositol Levels in Coronary Artery Disease Patients

Anton I. Rosenbaum, Yue Huang, Ruipeng Mu, Kristina S. Kovacina, ChaoYu Jin, B. Timothy Hummer, Meina Liang, Joseph S. Grimsby

This study shows that MEDI5884 increases phosphatidylinositol levels in CAD patients by inhibiting endothelial lipase, correlating with improved HDL function and reverse cholesterol transport.

bioRxiv · May 30, 2024 · PreprintPharmacology & Toxicology