Biased signaling via NtsR1 restrains food intake and weight gain in obese mice
Jariel Ramirez‐Virella, Katherine Black, Netanya F. Dennis, Raluca Bugescu, Katie Thompson, Steven H Olsen, Lauren M. Slosky, Zoé A. McElligott, Gina M. Leinninger
This study evaluates SBI-553, a biased NTSR1 modulator, showing it reduces food intake and weight regain in obese mice without affecting metabolic parameters.
bioRxiv · Sep 3, 2026 · PreprintPhysiology