Lauren M. Slosky

Biased signaling via NtsR1 restrains food intake and weight gain in obese mice

This study evaluates SBI-553, a biased NTSR1 modulator, showing it reduces food intake and weight regain in obese mice without affecting metabolic parameters.

Biased signaling at NTSR1 differentially regulates inhibitory synaptic transmission in the extended amygdala and suppresses motivated feeding in mice

This study investigates how biased signaling at NTSR1 modulates GABAergic transmission in the extended amygdala and affects feeding behavior in mice.

Design of allosteric modulators that change GPCR G protein subtype selectivity

This study designs allosteric modulators that alter GPCR G protein subtype selectivity by targeting the receptor-transducer interface, demonstrating predictable mechanisms for rational drug design.

Hidden Bias: GPCR Polymorphisms and the Genomic Landscape of β- Arrestin Signaling

The paper identifies SNPs in GPCRs that alter β-arrestin signaling bias and shows their potential impact on phenotypic variation.

β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents

This study evaluates the effects of SBI-553, a β-arrestin-biased allosteric modulator of NTSR1, on ethanol-related behaviors in rodents, finding reduced ethanol consumption and altered sensitivity to ethanol effects.

Establishment of Multi-stage Intravenous Self-administration in Mice

This paper establishes a multi-stage IVSA paradigm in mice for studying addiction, showing that behavioral traits predict vulnerability to drug seeking and relapse.