BioengineeringbioRxivPreprint
Sequencing-Free Protospacer-Adjacent Motif Discovery for Uncharacterized CRISPR-Cas9 Orthologs via Active Learning
Bogdan Kirillov, Aleksandra Vasileva, O. Fedorov…·Konstantin Severinov
This paper introduces an active learning method to discover PAMs for uncharacterized CRISPR-Cas9 orthologs without sequencing, reducing data requirements and validating it on known and novel Cas9 variants.
DOI 10.64898/2026.10.20.760532