Author

Aleksandra Vasileva

Peter the Great St. Petersburg Polytechnic UniversityORCID 0000-0002-0070-4898Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Mikhail A. KhodorkovskiiiD· 3 shared Alina Demkina· 2 shared Konstantin SeverinoviD· 2 shared Marina AbramovaiD· 2 shared Polina V MalyshevaiD· 2 shared A. N. Arseniev· 1 shared Aleksandr Andreevich AlekseeviD· 1 shared Aleksandra Andreevna Gorkovskaia· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersMolecular Biology

Mikhail A. KhodorkovskiiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Sequencing-Free Protospacer-Adjacent Motif Discovery for Uncharacterized CRISPR-Cas9 Orthologs via Active Learning

Bogdan Kirillov, Aleksandra Vasileva, O. Fedorov, Yuliya Kuz'mina, Matvey Kolesnik, Anna B. Trofimova, Alina Demkina, Viktoriia Ronchikova, Mariya Drozhzhina, Marina Abramova, Aleksandra Andreevna Gorkovskaia, Polina V Malysheva, Katherine Vilinski-Mazur, Mikhail A. Khodorkovskii, Maxim Panov, Konstantin Severinov

This paper introduces an active learning method to discover PAMs for uncharacterized CRISPR-Cas9 orthologs without sequencing, reducing data requirements and validating it on known and novel Cas9 variants.

bioRxiv · Oct 21, 2026 · PreprintBioengineering

Poly(ADP-ribose)polymerase1 facilitates the nucleosome disassembly

Aleksandr Andreevich Alekseev, Mikhail M. Kutuzov, Ekaterina A. Belousova, Aleksandra Vasileva, Ivan Goncharov, Mikhail A. Khodorkovskii, O. I. Lavrik

The paper shows PARP1 binding weakens nucleosome core contacts using optical tweezers.

bioRxiv · Jan 22, 2026 · PreprintMolecular Biology

Characterization of Streptococcus uberis Cas9 (SuCas9) - a Type II-A Ortholog Functional in Human Cells

Aleksandra Vasileva, Marina Abramova, Polina Selkova, A. N. Arseniev, Olga S. Musharova, Polina V Malysheva, Alina Demkina, Mikhail A. Khodorkovskii, Konstantin Severinov

This study characterizes SuCas9, a compact Cas9 ortholog from Streptococcus uberis, showing it can cleave DNA in vitro and function in human cells with a novel PAM sequence.

The CRISPR Journal · Dec 30, 2025Peer-reviewedMolecular Biology