A biologically-informed polygenic score identifiesendophenotypes and clinical conditions associated with the insulinreceptor function on specific brain regions
Shantala A. Hari Dass, Kathryn McCracken, Irina Pokhvisneva, Lawrence M. Chen, Elika Garg, Thao T. T. Nguyen, Zihan Wang, Bárbara Barth, Moein Yaqubi, Lisa M. McEwen, Julie L. MacIsaac, Josie C. Diorio, Michael Steffen Kobor, Kieran J. O’Donnell, Michael Joseph Meaney, Patrícia Pelufo Silveira
The paper introduces a biologically informed polygenic score for insulin receptor-related genes in mesocorticolimbic regions and shows it better predicts childhood impulsivity and early addiction risk than conventional scores.
EBioMedicine · Mar 26, 2019Peer-reviewedNeuroscience