Thao T. T. Nguyen

Internalizing Symptoms Associate with the Pace of Epigenetic Aging in Childhood

This study finds that internalizing symptoms in early childhood predict higher epigenetic age acceleration at age 6, which is linked to later internalizing symptoms.

Single cell transcriptomic analyses reveal the impact of bHLH factors ATOH7 and Neurog2 on human retinal organoid development

This study uses single-cell transcriptomics to show that ATOH7 and Neurog2 regulate human retinal progenitor states and neuroblast fate by modulating bHLH factor expression.

A biologically-informed polygenic score identifiesendophenotypes and clinical conditions associated with the insulinreceptor function on specific brain regions

The paper introduces a biologically informed polygenic score for insulin receptor-related genes in mesocorticolimbic regions and shows it better predicts childhood impulsivity and early addiction risk than conventional scores.

PRS-on-Spark: a novel, efficient and flexible approach for generating polygenic risk scores

PRS-on-Spark generates polygenic risk scores efficiently, supporting diverse data inputs and improving variance explained for major depression.