Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data
Amit Blumberg, Yixin Zhao, Yi-Fei Huang, Noah Dukler, Edward J. Rice, Alexandra G. Chivu, Katie Krumholz, Charles G. Danko, Adam C. Siepel
The paper introduces a method to estimate RNA half-lives using PRO-seq and RNA-seq data, finding correlations between RNA stability and splicing, miRNA binding, DNA methylation, and histone modifications.
BMC Biology · Feb 15, 2021Peer-reviewedGenomics