C9orf72-ALS mutation drives mitophagy impairments in iNeurons
James Lee, Sarah M. Granger, Katie Roome, Scott P. Allen, Laura Ferraiuolo, Pamela J. Shaw, Heather Mortiboys
This study shows that C9orf72-ALS mutation impairs mitophagy in iNeurons by reducing autophagosome production and ULK1 recruitment to mitochondria.
bioRxiv · Feb 28, 2025 · PreprintNeuroscience