Author

James Lee

University of SheffieldORCID 0000-0001-9843-6475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Heather MortiboysiD· 2 shared Laura FerraiuoloiD· 2 shared Pamela J. ShawiD· 2 shared Scott P. AlleniD· 2 shared Alexander J. WhitworthiD· 1 shared Álvaro Sánchez-MartíneziD· 1 shared Hiran A. PragiD· 1 shared Katie Roome· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersNeuroscience

Heather MortiboysORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintFeb 28, 2025

C9orf72-ALS mutation drives mitophagy impairments in iNeurons

James Lee, Sarah M. Granger, Katie Roome…·Heather Mortiboys

This study shows that C9orf72-ALS mutation impairs mitophagy in iNeurons by reducing autophagosome production and ULK1 recruitment to mitochondria.

DOI 10.1101/2025.02.28.640849

humanexperimental assay

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NeuroscienceLife Science AlliancePeer-reviewedJun 21, 2024

Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons

Wing Hei Au, Leonor Miller‐Fleming, Álvaro Sánchez-Martínez…·Alexander J. Whitworth

This study shows that activating the Keap1/Nrf2 pathway reduces mitochondrial dysfunction and motor deficits in C9orf72 ALS/FTD models and patient-derived neurons.

25 citationstop 2%

Drosophilahuman

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