The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic Hedgehog signalling
Leah Schembs, Ariane Willems, Kerstin Hasenpusch‐Theil, James D. Cooper, Katie Whiting, Karen Burr, Sunniva M. K. Bøstrand, Bhuvaneish Thangaraj Selvaraj, Siddharthan Chandran, Thomas Theil
This study shows that INPP5E negatively regulates Sonic Hedgehog signaling in human cortical organoids, promoting dorsal telencephalic identity and preventing ventralization.
bioRxiv · Jun 6, 2021 · PreprintDevelopmental Biology