Kerstin Hasenpusch‐Theil

ASD mutations in the ciliary gene CEP41 impact development of projection neurons and interneurons in a human cortical organoid model

The paper investigates how ASD mutations in CEP41 affect cortical neuron development in human organoids, finding altered cilia stability and changes in interneuron and projection neuron differentiation.

Identification of Pappa and Sall3 as Gli3 direct target genes acting downstream of cilia signalling in corticogenesis

This study identifies Pappa and Sall3 as Gli3 target genes downstream of cilia signaling in corticogenesis, showing their regulation by Gli3 in the dorsal telencephalon.

The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic Hedgehog signalling

This study shows that INPP5E negatively regulates Sonic Hedgehog signaling in human cortical organoids, promoting dorsal telencephalic identity and preventing ventralization.

A transient role of primary cilia in controlling direct versus indirect neurogenesis in the developing cerebral cortex

This study shows that primary cilia regulate direct versus indirect neurogenesis in the developing cerebral cortex, with Inpp5e mutations causing increased direct neurogenesis and layer V neuron overproduction.