Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions between Non-Coding RNAs in Cancer Cells
Jeffrey L. Schloßhauer, Sama Shamloo, Katja Schamrin, Jochen Imig
This study introduces a dual CRISPRi system to target lncRNAs in melanoma cells, enabling synthetic lethal screening to identify cancer-specific lncRNA interactions for therapeutic strategies.
Journal of Visualized Experiments · May 30, 2025Peer-reviewedCell Biology