Jochen Imig

HM-DyadCap captures and maps hmC/mC CpG dyads in mammalian DNA, revealing their enrichment in gene bodies and depletion at transcription start sites.

The paper identifies GAPDH as a non-canonical RNA-binding protein in AML that stabilizes transcripts and promotes translation, revealing its role in tumor proliferation.

The paper identifies lncRNAs involved in melanoma growth and metastasis using CRISPR-inhibition screens and validates their functional roles.

This study introduces a dual CRISPRi system to target lncRNAs in melanoma cells, enabling synthetic lethal screening to identify cancer-specific lncRNA interactions for therapeutic strategies.

This study shows Enoxacin reduces HIV-1 replication by downregulating hsa-miR-132-3p in T-cells, suggesting potential for antiviral therapy through miRNA modulation.