Inhibition of JAK2V617F-Driven Neoplastic Endothelial Dysfunction by IFNα as a Novel Antifibrotic Mechanism
Madeline J. Caduc, Mohamed H. Elsafi Mabrouk, Martin Graßhoff, Pia Wanner, Katrin Götz, Jessica E. Pritchard, Dickson W.L. Wong, Cristina Baquero López, Louisa Böttcher, Pinar Sönmez, Bärbel Junge, Eva Miriam Buhl, Sabrina Ernst, Gerhard Müller‐Newen, Michael Vogt, , Marcelo A. S. Toledo
This study identifies JAK2V617F zygosity-specific vascular changes in MPN and shows IFNα inhibits EndMT, offering a novel antifibrotic mechanism.
bioRxiv · Dec 23, 2024 · PreprintCancer Biology