Mohamed H. Elsafi Mabrouk

The paper shows that reversing PROTAC-induced ASH2L degradation restores H3K4me3, gene expression, and proliferation in senescent cells.

The paper shows that cell loss in RPE cells leads to mechanical changes that impair function, mimicking age-related decline in an in vitro model.

This study shows that epigenetic editing at age-associated CpGs can modulate the epigenetic aging landscape, affecting epigenetic clocks and inducing non-random bystander modifications.

This study identifies JAK2V617F zygosity-specific vascular changes in MPN and shows IFNα inhibits EndMT, offering a novel antifibrotic mechanism.

This study shows that substrate elasticity does not affect DNA methylation changes during iPSC differentiation, but epigenetic differences are observed between PDMS and TCP substrates.