Author

Gerhard Müller‐Newen

Universitätsklinikum AachenORCID 0000-0002-0820-7693Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Andrea Küster· 2 shared Henning Schurse· 2 shared Madeline J. CaduciD· 2 shared Marcelo A. S. ToledoiD· 2 shared Steffen KoschmiederiD· 2 shared A M Aransay· 1 shared Andrea AbaurreaiD· 1 shared Angela M. AraujoiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

Andrea Küster

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Unexpected functional role of the transactivation domain for nuclear import of STAT5

Sabrina Ernst, Merith Borgen-Möller, Andrea Küster, Henning Schurse, Gerhard Müller‐Newen

The paper identifies a role for the transactivation domain in STAT5 nuclear import, showing that a 12-amino-acid stretch and specific residues are essential for this process.

Communications Biology · Sep 26, 2026Peer-reviewedCell Biology

Oncostatin M cytokine promotes breast cancer progression by remodelling the extracellular matrix and activating integrin signalling in cancer cells

Peio Azcoaga, Andrea Abaurrea, Uxue Alvarez-Huesa, Paula Duch, Angela M. Araujo, Joanna I. López-Velazco, Zuhara Telletxea, Marta Rezola, Juana M. Flores, Gerhard Müller‐Newen, A M Aransay, Mikel Azkargorta, Félix Elortza, David Otaegui, Steve Stegen, , María M. Caffarel

bioRxiv · Jun 4, 2026 · PreprintCancer Biology

The V617F mutation in JAK2 renders myeloid cells more sensitive to IL-6-mediated gp130 signaling

Henning Schurse, Marcelo A. S. Toledo, Andrea Küster, Steffen Koschmieder, Madeline J. Caduc, Stefan Düsterhöft, Gerhard Müller‐Newen

This study shows that the JAK2 V617F mutation enhances IL-6 sensitivity by promoting gp130 dimerization and expression in myeloid cells, contributing to chronic inflammation in MPN.

bioRxiv · Oct 10, 2025 · PreprintCancer Biology

Inhibition of JAK2V617F-Driven Neoplastic Endothelial Dysfunction by IFNα as a Novel Antifibrotic Mechanism

Madeline J. Caduc, Mohamed H. Elsafi Mabrouk, Martin Graßhoff, Pia Wanner, Katrin Götz, Jessica E. Pritchard, Dickson W.L. Wong, Cristina Baquero López, Louisa Böttcher, Pinar Sönmez, Bärbel Junge, Eva Miriam Buhl, Sabrina Ernst, Gerhard Müller‐Newen, Michael Vogt, , Marcelo A. S. Toledo

This study identifies JAK2V617F zygosity-specific vascular changes in MPN and shows IFNα inhibits EndMT, offering a novel antifibrotic mechanism.

bioRxiv · Dec 23, 2024 · PreprintCancer Biology