Phosphorylation at S345 Converts HIF-2α from a Transcription Factor to an RNA binding protein
Adam Albanese, Leonard A. Daly, Katrin Prost-Fingerle, Luc G. Elliott, Sally O. Oswald, Gabrielle B. Ecclestone, Gemma M. Bell, Michael Batie, Daniel John Rigden, Claire E. Eyers, Joachim Fandrey, Niall Steven Kenneth, Violaine Sée, Sónia Rocha
This study shows that phosphorylation at S345 converts HIF-2α from a transcription factor to an RNA-binding protein, altering its function in hypoxia response.
bioRxiv · Apr 30, 2026 · PreprintMolecular Biology