Sónia Rocha

This study shows KDM2B regulates HIF-1 activity and expression through its JmjC and CxxC domains, affecting hypoxia response and cell survival.

This paper identifies hypoxia-related genes associated with prognosis in lung adenocarcinoma, finding DSG2, EIF6, and EXO1 as independent prognostic factors.

This study shows that phosphorylation at S345 converts HIF-2α from a transcription factor to an RNA-binding protein, altering its function in hypoxia response.

This study shows that CDDO-Me activates NRF2 to protect AC16 human cardiomyocytes from doxorubicin-induced toxicity by modulating p53 signaling, apoptosis, and ferroptosis.

The paper identifies NF-kappaB-dependent gene expression changes under hypoxia, showing its role in repression of hypoxia-downregulated genes and regulation of oxidative phosphorylation.

This study identifies PHD1-dependent hydroxylation of RepoMan at P604, showing it regulates mitotic progression by modulating PP2A interaction and H3T3 phosphorylation.

This study shows hypoxia and HIF regulate chromatin accessibility through locus-specific changes, which are reversible and can be mimicked by HIF stabilisation.

This study identifies SINHCAF/FAM60A as a component of the SIN3A-HDAC complex that regulates the hypoxia response and shows its inverse correlation with HIF2 mRNA levels, predicting cancer patient survival.

This study shows PHD2 hydroxylates CENP-N, regulating its localization and interaction with CENP-L, which affects CENP-A stability at centromeres.