Distinct regulation of collagen biosynthesis by hypoxia and vitamin C uncovers an essential role for CXCL12-CXCR4 signaling
Méline Ricol, Cindy Dieryckx, Camille Callies…·Violaine Sée
This study shows that ascorbic acid and hypoxia regulate collagen biosynthesis through distinct mechanisms, with AA enhancing secretion via CXCL12-CXCR4 signaling and hypoxia increasing hydroxylation.