The Joubert gene TMEM67 is required for the correct establishment of spinal dorsal identities in human organoids.
Antonia Wiegering, Katya Bools, Isabelle Anselme, Laura Metayer-Derout, Olivier Mercey, Estelle Balissat, Yohana Bijek, Martin Catala, Sylvie Schneider‐Maunoury, Aline Stedman
This study shows that TMEM67 is essential for proper dorsal spinal cord patterning in human organoids, with loss of TMEM67 disrupting interneuron specification and altering BMP4 signaling.
bioRxiv · Jan 20, 2026 · PreprintDevelopmental Biology