Nutrient-limited conditions reveal the activity of a minor groove binder, MGB-BP-3, against Escherichia coli
Kaveh Eskandari, Louise C Young, Jessica M. A. Blair, Katarína Oravcová, Fraser J. Scott
This study shows that MGB-BP-3, a minor groove binder, is more effective against Gram-negative bacteria like E. coli under nutrient-limited conditions than in rich media, with in vivo efficacy in a Galleria mellonella model.
bioRxiv · Dec 23, 2025 · PreprintMicrobiology