A click chemistry-based biorthogonal approach for the detection and identification of protein lysine malonylation for osteoarthritis research
Anupama Binoy, Pandurangan Nanjan, Kavya Chellamuthu, Huanhuan Liu, Shouan Zhu
This study introduces MA-diyne, a click chemistry probe for detecting lysine malonylation in proteins, revealing its role in osteoarthritis by identifying targets and showing Sirtuin 5 regulation.
ACS Bio & Med Chem Au · May 8, 2025Peer-reviewedBiochemistry