Author

Shouan Zhu

Heritage CollegeORCID 0000-0002-4973-1504Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Organism:human· 1

Frequent Co-Authors

Anupama BinoyiD· 2 shared Abhijit SukuliD· 1 shared Anna E. Miller· 1 shared Birgit SchillingiD· 1 shared Craig R. G. WillisiD· 1 shared Huanhuan Liu· 1 shared Huanhuan LiuiD· 1 shared Jacob RoseiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Anupama BinoyORCID

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2 papers

Recent·Most cited

A click chemistry-based biorthogonal approach for the detection and identification of protein lysine malonylation for osteoarthritis research

Anupama Binoy, Pandurangan Nanjan, Kavya Chellamuthu, Huanhuan Liu, Shouan Zhu

This study introduces MA-diyne, a click chemistry probe for detecting lysine malonylation in proteins, revealing its role in osteoarthritis by identifying targets and showing Sirtuin 5 regulation.

ACS Bio & Med Chem Au · May 8, 2025Peer-reviewedBiochemistry

Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

Huanhuan Liu, Anupama Binoy, Siqi Ren, T. C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Abhijit Sukul, Joanna Bons, Jacob Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu

This study identifies Sirt5's role in regulating chondrocyte metabolism and osteoarthritis through lysine malonylation, showing its dysregulation contributes to OA in aging and obesity.

Arthritis & Rheumatology · Apr 3, 2025Peer-reviewedCell Biology