Mechanobiological Conditioning of Mesenchymal Stem Cells Enhances Therapeutic Angiogenesis by Inducing a Hybrid Pericyte-Endothelial Phenotype
Jason Lee, Kayla Henderson, Miguel Armenta-Ochoa, Austin Veith, Pablo Maceda, Eun Yoon, Lara Samarneh, Mitchell Wong, Andrew Dunn, Aaron Baker
This study shows that combining mechanical strain and kinase inhibitors enhances mesenchymal stem cells to express pericyte and endothelial markers, improving their angiogenic capabilities.
bioRxiv · Dec 5, 2018 · PreprintBioengineering