Mutant IDH impairs chromatin binding by PDGFB to promote chromosome instability
Rachel Naomi Curry, Malcolm F. McDonald, Peihao He, Brittney Lozzi, Yeunjung Ko, Isabella O’Reilly, Anna Rosenbaum, Wookbong Kwon, Leyla E. Fahim, Joshua M. Marcus, Noah Powell, Su Wang, Jin Ma, Asha S. Multani, Dong‐Joo Choi, , Ganesh S. Rao
This study shows that mutant IDH impairs PDGFB's chromatin binding, leading to chromosome instability and accelerated gliomagenesis.
bioRxiv · Feb 20, 2025 · PreprintCancer Biology