Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
Kira Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D. Galbraith, Joaquin Maximiliano Espinosa, David L. Bentley, Mary Ann Allen, Robin D. Dowell, Dylan J. Taatjes
This study shows that inhibiting Mediator kinases CDK8/CDK19 suppresses hyperactive IFN signaling in Down syndrome by affecting transcription, splicing, and lipid metabolism.
eLife · Feb 10, 2025Peer-reviewedMolecular Biology