Taylor Jones

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

This study shows that inhibiting Mediator kinases CDK8/CDK19 suppresses hyperactive IFN signaling in Down syndrome by affecting transcription, splicing, and lipid metabolism.

A transcription factor (TF) inference method that broadly measures TF activity and identifies mechanistically distinct TF networks

TF profiler infers transcription factor activity from PRO-seq and GRO-seq data, identifying three distinct TF classes based on regulatory roles.

Atlas of nascent RNA transcripts reveals enhancer to gene linkages

The paper identifies over 800,000 bidirectional transcription regions in human samples and links them to genes through correlated transcription, enriched for disease SNPs and supported by 3D data.

Cellular zinc status alters chromatin accessibility and binding of transcription factor TP53 to genomic sites

The paper shows that changes in labile zinc levels affect chromatin accessibility and TP53 binding to DNA.

Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide

The paper develops a stapled peptide that inhibits p53-Mediator interaction, suppressing p53 transcriptional activity in cancer cells.