Dylan J. Taatjes

This study identifies CDK7-dependent mechanisms regulating RNAPII function at gene 5'- and 3'-ends through biochemical reconstitution and multi-omics analysis.

This study shows that inhibiting Mediator kinases CDK8/CDK19 suppresses hyperactive IFN signaling in Down syndrome by affecting transcription, splicing, and lipid metabolism.

This study shows largazole suppresses superenhancer accessibility by inhibiting SP1 and BRD4, leading to mitotic chromosome misalignment and cell cycle arrest.

This study develops RIFT, a real-time in-vitro assay to visualize RNAPII transcription, revealing IDR-dependent activation mechanisms and condensate effects on transcription.

TF profiler infers transcription factor activity from PRO-seq and GRO-seq data, identifying three distinct TF classes based on regulatory roles.

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.

The paper develops a stapled peptide that inhibits p53-Mediator interaction, suppressing p53 transcriptional activity in cancer cells.

TFEA quantifies transcription factor activity changes from perturbation data, identifying key regulators and temporal regulatory networks.

The paper identifies nuclear interactors of DYRK1A, revealing its role in DNA damage repair and providing a resource for further functional studies.