Lynn Sanford

The paper identifies an ancient retrotransposon-derived IL18R1-Short isoform that modulates IL-18 signaling across species.

The paper investigates metal homeostasis changes in quiescent cells induced by different triggers and finds trigger-specific remodeling of metal pools and associated gene expression.

This study identifies CDK7-dependent mechanisms regulating RNAPII function at gene 5'- and 3'-ends through biochemical reconstitution and multi-omics analysis.

This study shows that inhibiting Mediator kinases CDK8/CDK19 suppresses hyperactive IFN signaling in Down syndrome by affecting transcription, splicing, and lipid metabolism.

TF profiler infers transcription factor activity from PRO-seq and GRO-seq data, identifying three distinct TF classes based on regulatory roles.

The paper identifies over 800,000 bidirectional transcription regions in human samples and links them to genes through correlated transcription, enriched for disease SNPs and supported by 3D data.

The paper shows that changes in labile zinc levels affect chromatin accessibility and TP53 binding to DNA.

The paper uses genomics techniques to analyze transcriptional responses to wood smoke particles and identifies rapid AHR signaling dynamics and interactions with NFkB.

The paper quantifies Zn2+ dynamics in dissociated mouse hippocampal neurons under two stimulation methods, finding that glutamate stimulation leads to more sustained Ca2+ and larger Zn2+ increases compared to high KCl.