Multidimensional Single-Cell Transcriptomic Profiling of Uterine Leiomyosarcomas Reveals Distinct Tumor States with Inferred Therapeutic Vulnerabilities
Maria Moozhiyil Korah, James Paul Agolia, Biren Reddy, Renceh A. B. Flojo, Amanda Costa Gonçalves, Lilin Wang, Rishik Bethi, Wesley Bobst, Brooke Liang, Kaylin A. Yip, Angela D Tabora, Chia-Hsin Hsu, Rosyli F. Reveron‐Thornton, Chuner Guo, Robert F. Gruener, , Daniel Delitto
This study uses single-cell and spatial transcriptomics to identify distinct tumor states in uterine leiomyosarcomas and proposes drug targets based on these states.
bioRxiv · Nov 17, 2025 · PreprintCancer Biology