Chuner Guo

The paper constructs a pan-cancer single-cell atlas to improve tumor identity inference and identify genetic vulnerabilities by integrating high-quality malignant cells across multiple cancers.

This study uses single-cell and spatial transcriptomics to identify distinct tumor states in uterine leiomyosarcomas and proposes drug targets based on these states.

This paper introduces self-reporting transposons (SRTs) and the scCC assay to simultaneously capture gene expression and TF binding in single cells, demonstrating their use in cultured cells and mouse cortex.

CellTag Indexing enables genetic barcode-based multiplexing for single-cell genomics, allowing simultaneous sample identification and transcriptional analysis across diverse cell types.

This paper introduces a lineage-tracing method called CellTagging to study clonal dynamics in direct lineage reprogramming from fibroblasts to induced endoderm progenitors, revealing rare successful reprogramming events and clonal instability.