DNAM-1 immunoreceptor integrates innate and adaptive immune programs to drive intestinal inflammation
Natsuki Ide, kazuki Sato, Kyoko Oh‐oka, Mariana Sylvia Almeida, Fumie Abe, Tae-hyeong Kim, Chigusa Nakahashi-Oda, Kazuko Shibuya, Akira Shibuya
This study identifies DNAM-1 as a key integrator of innate and adaptive immune responses in intestinal inflammation, showing it drives colitis through distinct mechanisms in ILC3s and dendritic cells and highlights its potential as a therapeutic target.
bioRxiv · Apr 1, 2026 · PreprintImmunology