Cortical α-synuclein pathology induces neuronal hypoactivity andcircuit changes but not functional impairments in a model of early Lewy body dementia
Aye Theint Theint, Noe Cazares, Shujing Zhang, Ninglong Zhang, Rochelle Mosley, Kazushisa Ishida, Makoto Higuchi, Chao Peng, William Zeiger
This study shows that α-synuclein pathology in mice visual cortex reduces neuronal activity in affected cells and alters population activity but does not impair visuoperceptual function.
bioRxiv · Jul 31, 2025 · PreprintNeuroscience