Makoto Higuchi

Dopamine shapes brain metastate dynamics

This study investigates how dopamine affects brain metastate dynamics using a combination of PET, fMRI, and hidden Markov modeling, finding that dopamine shifts the balance between internally oriented and sensorimotor-perceptual brain states.

Cortical α-synuclein pathology induces neuronal hypoactivity andcircuit changes but not functional impairments in a model of early Lewy body dementia

This study shows that α-synuclein pathology in mice visual cortex reduces neuronal activity in affected cells and alters population activity but does not impair visuoperceptual function.

Chronic behavioral manipulation via orally delivered chemogenetic actuator in macaques

This study evaluates orally delivered DCZ for chronic chemogenetic control of neuronal activity in macaques, showing prolonged effects and working memory impairments without desensitization.

MRS-measured Glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice

The paper shows that MRS-measured Glutamate and GABA levels in awake mice correlate with excitatory and inhibitory neural activities during stimulation and in a Dravet syndrome model.