Author

Ke Z. Shan

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:development & morphogenesis· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Huanghe YangiD· 2 shared Pengfei LiangiD· 2 shared Yang ZhangiD· 2 shared Augustus J. LowryiD· 1 shared Gowthami M. ArepallyiD· 1 shared Liping FengiD· 1 shared Marilyn J. TeleniD· 1 shared Martha D. Delahunty· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPhysiology

Huanghe YangORCID

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2 papers

Recent·Most cited

Targeting PIEZO1-TMEM16F Coupling to Mitigate Sickle Cell Disease Complications

Pengfei Liang, Yaping Wan, Ke Z. Shan, Ryan Chou, Yang Zhang, Martha D. Delahunty, Sanjay Khandelwal, Samuel Francis, Gowthami M. Arepally, Marilyn J. Telen, Huanghe Yang

This paper identifies PIEZO1-TMEM16F coupling as a mechanism driving phosphatidylserine exposure in sickle red blood cells and proposes targeting this pathway to reduce disease complications.

American Journal of Hematology · Oct 8, 2025Peer-reviewedPhysiology

PIEZO1 Drives Trophoblast Fusion and Placental Development

Yang Zhang, Ke Z. Shan, Pengfei Liang, Augustus J. Lowry, Liping Feng, Huanghe Yang

This study shows PIEZO1 is essential for trophoblast fusion and placental development in mice by activating TMEM16F and phosphatidylserine externalization.

Nature Communications · Jul 26, 2025Peer-reviewedCell Biology