Author

Ryan Chou

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Andrew Njagi MugoiD· 2 shared Dinesh C. IndurthiiD· 1 shared Feng Qin· 1 shared Feng QiniD· 1 shared Gaya Prasad YadaviD· 1 shared Gowthami M. ArepallyiD· 1 shared Huanghe YangiD· 1 shared Ke Z. Shan· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersPhysiology

Andrew Njagi MugoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Targeting PIEZO1-TMEM16F Coupling to Mitigate Sickle Cell Disease Complications

Pengfei Liang, Yaping Wan, Ke Z. Shan, Ryan Chou, Yang Zhang, Martha D. Delahunty, Sanjay Khandelwal, Samuel Francis, Gowthami M. Arepally, Marilyn J. Telen, Huanghe Yang

This paper identifies PIEZO1-TMEM16F coupling as a mechanism driving phosphatidylserine exposure in sickle red blood cells and proposes targeting this pathway to reduce disease complications.

American Journal of Hematology · Oct 8, 2025Peer-reviewedPhysiology

Harnessing Protein Unfolding for Thermosensing: Structural Insights from TRPV3

Andrew Njagi Mugo, Dinesh C. Indurthi, Ryan Chou, Gaya Prasad Yadav, Liguo Wang, Feng Qin

This study reveals a structural mechanism for thermosensing in TRPV3 channels, showing that extreme thermosensitivity arises from protein unfolding and dynamic changes rather than localized sensors.

bioRxiv · Sep 17, 2025 · PreprintPhysiology

Protein Dynamics Underlies Strong Temperature Dependence of Heat Receptors

Andrew Njagi Mugo, Ryan Chou, Feng Qin

The paper shows that temperature sensing in TRPV1 channels is linked to protein unfolding and thermal instability, not conventional allosteric mechanisms.

Proceedings of the National Academy of Sciences · Dec 30, 2024Peer-reviewedBiophysics