Characterization of Cytochrome P450-Mediated Metabolism of Δ8-tetrahydrocannabinol in vitro
Keiann T. Simon, Yue Winnie Wen, Yuqi Emily Dong, Aurora K. Authement, Jiayao Chen, Kenneth E. Thummel, Nina Isoherranen
This study identifies the main cytochrome P450 enzymes responsible for metabolizing Δ8-THC in human liver microsomes and shows that CYP2C9 is the primary catalyst for its 11-hydroxylation.
bioRxiv · Oct 19, 2026 · PreprintPharmacology & Toxicology