Author

Kenneth E. Thummel

University of WashingtonORCID 0000-0002-7799-3739Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron C. EricssoniD· 1 shared Aurora K. AuthementiD· 1 shared Hanna ChoiiD· 1 shared Inga EricksoniD· 1 shared Jiayao Chen· 1 shared Keiann T. Simon· 1 shared Kristen Peagler· 1 shared Melissa L. Barker‐HaliskiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Aaron C. EricssonORCID

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2 papers

Recent·Most cited

Characterization of Cytochrome P450-Mediated Metabolism of Δ8-tetrahydrocannabinol in vitro

Keiann T. Simon, Yue Winnie Wen, Yuqi Emily Dong, Aurora K. Authement, Jiayao Chen, Kenneth E. Thummel, Nina Isoherranen

This study identifies the main cytochrome P450 enzymes responsible for metabolizing Δ8-THC in human liver microsomes and shows that CYP2C9 is the primary catalyst for its 11-hydroxylation.

bioRxiv · Oct 19, 2026 · PreprintPharmacology & Toxicology

Intestinal Dysbiosis Alters Acute Seizure Burden and Antiseizure Medicine Activity in the Theiler's Virus Model of Encephalitis

Inga Erickson, Stephanie Davidson, Hanna Choi, S Rho, Michelle A. Guignet, Kristen Peagler, Kenneth E. Thummel, Aaron C. Ericsson, Melissa L. Barker‐Haliski

This study shows that antibiotic-induced gut dysbiosis alters seizure burden and carbamazepine anticonvulsant activity in a Theiler's virus encephalitis model without affecting drug plasma concentrations.

Epilepsia · Mar 28, 2025Peer-reviewedNeuroscience