Pharmacology & ToxicologybioRxivPreprint
Characterization of Cytochrome P450-Mediated Metabolism of Δ8-tetrahydrocannabinol in vitro
Keiann T. Simon, Yue Winnie Wen, Yuqi Emily Dong…·Nina Isoherranen
This study identifies the main cytochrome P450 enzymes responsible for metabolizing Δ8-THC in human liver microsomes and shows that CYP2C9 is the primary catalyst for its 11-hydroxylation.
DOI 10.64898/2026.10.12.758575