Incorporating physics to overcome data scarcity in predictive modeling of protein function: a case study of BK channels
Erik B. Nordquist, Guohui Zhang, Shrishti Barethiya, Nathan Ji, Kelli M. White, Lu Han, Zhiguang Jia, Jingyi Shi, Jianmin Cui, Jianhan Chen
The paper develops a predictive model for BK channel voltage gating using physics-based features and random forest, achieving accurate predictions with limited mutational data.
PLoS Computational Biology · Sep 15, 2023Peer-reviewedBioinformatics