Author

Guohui Zhang

Washington University in St. LouisORCID 0000-0001-6905-0637Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:genome assembly· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:software / tool· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Jianmin CuiiD· 2 shared Alice ButleriD· 1 shared B Q LiiD· 1 shared Erik B. NordquistiD· 1 shared Gonzalo BudelliiD· 1 shared Haitao ZhangiD· 1 shared Jianhan CheniD· 1 shared Jingyi ShiiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioinformatics

Jianmin CuiORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintFeb 13, 2025

Pneumo-Typer: integrated genomic surveillance tool for capsule genotype, serotype and sequence type in Streptococcus pneumoniae informs vaccine strategies

Xiangyang Li, Haitao Zhang, Yaoyao Zhu…·Zhongrui Ma

Pneumo-Typer identifies capsule genotype variations in Streptococcus pneumoniae genomes, revealing CapT diversity and informing vaccine strategies.

1 citation

whole-genome sequencingstatistical model

𝕏 PostBluesky

BioinformaticsPLoS Computational BiologyPeer-reviewedSep 15, 2023

Incorporating physics to overcome data scarcity in predictive modeling of protein function: a case study of BK channels

Erik B. Nordquist, Guohui Zhang, Shrishti Barethiya…·Jianhan Chen

The paper develops a predictive model for BK channel voltage gating using physics-based features and random forest, achieving accurate predictions with limited mutational data.

8 citations

protein structureprotein sequence

𝕏 PostBluesky

NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedJun 8, 2020

Coupling of Ca2+ and voltage activation in BK channels through the αB helix/voltage sensor interface

Yanyan Geng, Zengqin Deng, Guohui Zhang…·Karl L. Magleby

This study investigates how the B helix/voltage sensor interface in BK channels couples Ca2+ and voltage activation, showing its role in transducing both signals to pore opening.

23 citations

statistical model

𝕏 PostBluesky