Jianmin Cui

This study investigates how KCNE1 and KCNE3 modulate KCNQ1 gating through PIP2-dependent mechanisms, revealing distinct roles in voltage sensitivity and GPCR regulation across cell types.

The paper engineers hTRPV4 to create an ultrasound-sensitive actuator for sonogenetics, showing improved mechano-sensitivity and reduced sensitivity to other stimuli.

This paper identifies the fully activated open state of KCNQ1 as critical for β-adrenergic stimulation of IKs channels, showing that modulators enhancing this state can restore function in LQT1 mutants.

This study shows that reducing midline thalamus neuron bursting prevents absence seizures in a mouse model by enhancing vigilance and suppressing seizure activity.

The paper develops a predictive model for BK channel voltage gating using physics-based features and random forest, achieving accurate predictions with limited mutational data.

This study investigates the neuronal mechanism of a BK channelopathy in absence epilepsy and movement disorders using a knock-in mouse model and finds that BK channel inhibition can mitigate seizures and motor deficits.

This paper demonstrates that TRPV1 can be used for noninvasive, cell-type specific, and spatiotemporally controlled modulation of mammalian brain activity using focused ultrasound.

This study investigates how the B helix/voltage sensor interface in BK channels couples Ca2+ and voltage activation, showing its role in transducing both signals to pore opening.