Zhiguang Jia

Atomistic Simulation of Voltage Activation of a Truncated BK Channel

The paper uses atomistic simulations to study voltage activation of BK channels, revealing unique VSD movement and coupling mechanisms distinct from canonical Kv channels.

Small molecule NS11021 promotes BK channel activation by increasing inner pore hydration

This paper investigates how the small molecule NS11021 activates BK channels by increasing inner pore hydration through atomistic simulations.

Incorporating physics to overcome data scarcity in predictive modeling of protein function: a case study of BK channels

The paper develops a predictive model for BK channel voltage gating using physics-based features and random forest, achieving accurate predictions with limited mutational data.